The moments that almost break you… and how they build you.

 

When a friend was 25, his business looked great from the outside. Inside, it was a complete disaster. Jobs falling apart. Banks calling nonstop. People telling him to quit.

There were nights he sat in a freezing car wondering if this whole thing was a mistake.

But he didn’t quit.

And I’m glad he didn’t, because those were the exact moments that made him who he is today.

The truth is, success doesn’t come from comfort. It comes from pressure. It comes from staying in the game when most people tap out.

That’s how you get sharp. That’s how you get better. That’s how you build something that lasts.

A New Clue to Why Heart Attacks Are Less Severe at Night

It’s been known for some time that myocardial infarctions, or heart attacks, tend to be more severe in the morning than they are at nighttime. Daily fluctuations in stress hormones and blood pressure are well documented and point to the important role circadian rhythm plays in cardiovascular health. But those aren’t the only factors.

Immune responses also follow the body’s natural biological clock. Research has shown that neutrophils—the most common type of white blood cell—often cause more damage to tissues at the site of inflammatory injuries, such as heart attacks, during the day than at night.

Neutrophils have been referred to by cardioimmunology experts as first responders for the speed at which they arrive to a trauma, but they’ve also been labeled as foot soldiers and demolition crews based on the havoc they wreak in the process of fighting off potential infections.

“They’re the first sentinel, but they come fully loaded,” said Douglas Mann, MD, the Ada L. Steininger Professor of Cardiology and professor of medicine, cell biology, and physiology at Washington University School of Medicine in St Louis. “They’re shooting at everything and dumping a lot of toxic granules on the environment. They are indiscriminate in terms of their ability to destroy, and they take out healthy cells in the process.”

Scientists have explored the connection between neutrophils and the severity of daytime heart attacks, but now, a new study may provide a novel clue into not just why neutrophils are diurnally aggressive but how, with some tweaks to their internal clocks, they may be modified to do less damage during noninfectious “sterile inflammation” while still eliminating pathogens.

What the researchers were able to show, Mann said, was a way “to train the foot soldiers” and minimize their collateral damage. “That’s a very big deal,” he said.

President Donald Trump launched TrumpRx yesterday Feb 5, 2026-

 

—a direct-to-consumer website where Americans can search for medications and compare prices. Consumers can then purchase the medications through pharmaceutical companies’ websites, with or without insurance. See the website here.

The medications offered on TrumpRx require a prescription, including weight-loss drugs Wegovy and Zepbound. Some, like the blood thinner Plavix, will cost as low as $16 per month, while more expensive drugs can exceed $2K. TrumpRx aims to reduce costs by featuring price comparisons, giving more choice to consumers. However, if generic versions of a drug are not featured on the site, or consumers fail to apply savings from insurance, they could miss out on cheaper alternatives. Experts recommend checking insurance coverage to avoid overpaying for drugs.

Drug prices have ballooned in recent decades, increasing at three times the rate of inflation. Heart and diabetes medications are especially driving up costs.

ASK CHATGPT TO BEAT UP YOUR IDEAS

Two brains are better than one, but if you're a team of one, make AI your second brain. Toss your idea into ChatGPT and ask: “What’s missing? How could this idea get more engagement?”

You're definitely a better strategist than the computer, but outside perspective can be prettyyyy valuable.

WRITE BETTER HOOKS FOR YOUR FAVORITE IDEA

So you've got a smart idea for your brand's social post, but you don't know how to set up the first 3 seconds with a good hook. You should just ask ChatGPT.

Feed it a paragraph about your idea, then ask “Write 10 hooks for this post in different tones. Consider funny, emotional, controversial, and data-driven.”

Define what success looks like now.

For employees, one of the hardest parts of a transition is not knowing what’s expected of them. Even highly engaged performers can lose confidence in the company and faith in their abilities if their goals aren't clear. 

That’s why it's crucial to give your team some amount of clarity, even if you don't have all the answers yet. 

Focus on short-term goals and set immediate priorities. Clarify which initiatives are on hold, what the new focus is, and what great work looks like under the current conditions. 

This information gives your employees something tangible to work with, so they don't feel lost.

 

Good question: “Have I clearly articulated what my team should prioritize right now?”

Focus on progress

When plans change, it's natural to feel like your team's previous work was wasted. 

As a leader, one of the most powerful things you can do is honor the effort that’s already been put in and show that it still matters. 

Frame the pivot as a continuation of growth, not a reset. For example: “What you learned in this project is setting us up to move faster in this new direction.” 

When people can see how their skills and progress still contribute to something meaningful, they’re less likely to feel bitter about the past and more likely to re-engage with purpose.

 

Ask: “How can I show the team that what they’ve already built connects this shift?”